microbiology chapter 1 test bank

Correct Answer: B

Rationale: The correct answer is B: Aminoglycosides. Aminoglycosides are antibiotics that act by binding to the 30S ribosomal subunit, disrupting protein synthesis in bacteria. This interaction affects the ribosomes directly, leading to inhibition of bacterial protein production. Penicillins (A) work by inhibiting cell wall synthesis, Sulfonamides (C) target folic acid synthesis, and Quinolones (D) inhibit DNA gyrase. These mechanisms do not directly affect the ribosomes, making them incorrect choices in this context.

Correct Answer: A

Rationale: The correct answer is A because spores are heat-resistant and require high temperatures for destruction. Autoclaving at 121�C for 15-20 minutes ensures spore destruction due to the high pressure and temperature. Choice B (heating to 80�C) is insufficient to destroy spores. Choice C (boiling at 100�C for 10 minutes) is also inadequate as spores require higher temperatures for elimination. Choice D (None of them) is incorrect as autoclaving is the standard method for spore sterilization.

Correct Answer: D

Rationale: The correct answer is D: Granulomatosis. The appearance of a 10 mm papule 48 hours after the Mantoux test indicates a delayed-type hypersensitivity reaction, which is characteristic of granulomatosis. This type of reaction involves activation of macrophages and T cells, leading to the formation of granulomas. Granulomas are organized collections of immune cells that wall off the antigen, in this case, the tuberculin antigen. A, B, and C are incorrect: A: Cellular cytotoxicity involves the destruction of target cells by immune cells such as cytotoxic T cells or natural killer cells. This mechanism is not associated with the delayed-type hypersensitivity reaction seen in granulomatosis. B: Anaphylaxis is a rapid and severe allergic reaction involving IgE-mediated release of histamine and other inflammatory mediators. This is not the mechanism underlying the delayed-type hypersensitivity reaction in the Mantoux test. C: Antibody-dependent cytotoxic

Correct Answer: A

Rationale: Step-by-step rationale for why Answer A (Sabouraud's) is correct: 1. Sabouraud's agar is a selective medium for fungi. 2. Candida is a type of fungus causing candidosis. 3. Sabouraud's agar promotes fungal growth. 4. Candida will grow on Sabouraud's agar, confirming the diagnosis. 5. Other choices are for bacterial culture, not suitable for fungal growth. Summary: - Endo, Jensen's, and Roux are not appropriate for fungal culture. - Sabouraud's agar specifically supports fungal growth, making it the correct choice for confirming candidosis.

Correct Answer: A

Rationale: The correct answer is A: Salk and Sabin vaccines are vaccines against polio. Both Salk and Sabin vaccines are indeed vaccines specifically developed to prevent polio. The Salk vaccine is an inactivated polio vaccine, while the Sabin vaccine is an oral live attenuated vaccine. Therefore, choice B is incorrect as the Sabin vaccine is live attenuated, not inactivated. Choice C is also incorrect because the Salk vaccine is inactivated, not live attenuated. Choice D is incorrect because not all statements are true; only statement A is accurate.