Microbiology Basic and Clinical Principles Test Bank

Correct Answer: A

Rationale: The correct answer is A: Delayed hypersensitivity reaction. In granuloma development in tuberculosis, macrophages present antigen to T cells, leading to a delayed hypersensitivity reaction. This triggers the recruitment of more macrophages and formation of granulomas. Antibody-dependent cytotoxicity (B) and complement-dependent cytotoxicity (C) involve antibodies and complement proteins in immediate hypersensitivity reactions, which are not the primary mechanisms in tuberculosis. Anaphylactic reaction (D) is an acute systemic allergic reaction mediated by IgE antibodies, not relevant to granuloma formation in tuberculosis.

Correct Answer: D

Rationale: Rationale: 1. Streptococcus pneumoniae is a common cause of bacterial pneumonia. 2. Mycobacterium tuberculosis can cause a type of pneumonia called tuberculosis. 3. Escherichia coli is not typically associated with pneumonia. 4. "All of the above" includes both Streptococcus pneumoniae and Mycobacterium tuberculosis, which are known to cause pneumonia. Therefore, D is the correct answer.

Correct Answer: A

Rationale: The correct answer is A: BCG. BCG vaccine is commonly used for tuberculosis prevention because it provides immunity against Mycobacterium tuberculosis. Mantoux is a test, not a vaccine. DTaP vaccine is for diphtheria, tetanus, and pertussis, not tuberculosis. Anatoxin is a type of toxoid vaccine, not used for tuberculosis prevention. BCG vaccine has been shown to be effective in preventing severe forms of tuberculosis in infants, making it the appropriate choice in this scenario.

Correct Answer: A

Rationale: The correct answer is A: Neisseria meningitidis. This is because Neisseria meningitidis is a Gram-negative diplococcus known to cause bacterial meningitis, presenting with fever, headache, and neck stiffness. It is a common cause of meningitis in young adults and teenagers. Streptococcus pneumoniae (B) is a Gram-positive bacteria and a common cause of bacterial pneumonia, not meningitis. Haemophilus influenzae (C) is a Gram-negative coccobacillus that can cause meningitis, but it is less common in adults. Klebsiella pneumoniae (D) is a Gram-negative bacillus known to cause pneumonia and urinary tract infections, not meningitis.

Correct Answer: C

Rationale: The correct answer is C: Flaviviridae. Dengue virus belongs to the Flaviviridae family because it is a flavivirus. Flaviviruses are a group of RNA viruses known to cause diseases in humans, such as dengue fever, Zika virus, and yellow fever. This family is characterized by its single-stranded, positive-sense RNA genome and enveloped virion structure. Hepadnaviridae (choice A), Parvoviridae (choice B), and Picornaviridae (choice D) are all different families of viruses that do not include the dengue virus. Hepadnaviridae includes hepatitis B virus, Parvoviridae includes parvoviruses, and Picornaviridae includes enteroviruses like poliovirus.