Microbiology Basic and Clinical Principles Test Bank

Correct Answer: A

Rationale: The correct answer is A: Metronidazole. Rationale: 1. Metronidazole is the drug of choice for amebic dysentery due to its effectiveness against the causative agent, Entamoeba histolytica. 2. Metronidazole has good tissue penetration and is able to reach the site of infection in the gut. 3. It is a bactericidal drug that acts by disrupting the DNA structure of the parasite. 4. Metronidazole is well-absorbed orally and has minimal side effects. Summary of other choices: B: Furazolidonum - Not the drug of choice for amebic dysentery. It is primarily used for treating bacterial diarrhea. C: Levomycetin - Not effective against Entamoeba histolytica and not recommended for amebic dysentery. D: Phthalazol - Not commonly used for amebic dysentery treatment. Metronidazole is preferred due

Correct Answer: B

Rationale: The correct answer is B. Immunity after a single tetanus vaccination is of limited duration, usually around 10 years. Booster vaccinations are needed to maintain protection due to waning immunity over time. Choice A is incorrect as immunity is not usually lifelong. Choice C is incorrect as tetanus toxoid is a sterile vaccine and does not cause infection. Choice D is also incorrect as there is a correct answer, which is B.

Correct Answer: A

Rationale: The correct answer is A: Corynebacterium diphtheriae. The presence of rod-shaped bacteria with dark blue polar granules suggests the presence of Corynebacterium diphtheriae, the causative agent of diphtheria. This bacterium is known for causing sore throat and fever, and the characteristic appearance on smear helps identify it. Streptococcus pyogenes (Choice B) typically appears as chains of cocci and is associated with strep throat. Haemophilus influenzae (Choice C) is a small, pleomorphic Gram-negative coccobacillus and is more commonly associated with respiratory infections. Klebsiella pneumoniae (Choice D) is a Gram-negative bacillus and is not typically associated with sore throat and fever in children.

Correct Answer: B

Rationale: The correct answer is B: Simpler. Prokaryotic cytoplasm is simpler than eukaryotic cytoplasm because prokaryotic cells lack membrane-bound organelles such as a nucleus, mitochondria, and endoplasmic reticulum that are present in eukaryotic cells. Prokaryotic cytoplasm contains fewer components and structures compared to eukaryotic cytoplasm, making it less complex. Therefore, the prokaryotic cytoplasm is simpler in structure. Choices A, C, and D are incorrect because prokaryotic cytoplasm is not more complex than eukaryotic cytoplasm, there is a clear difference in structure between prokaryotic and eukaryotic cytoplasm, and the statement "None of the above" is not accurate as the correct answer is B.

Correct Answer: A

Rationale: The correct answer is A: ED50. The time response does not measure the ED50 because ED50 refers to the effective dose needed to produce a response in 50% of the population, which is a dose-related concept, not a time-related one. Peak effect time, onset of response, and threshold level are all time-related measures in pharmacology. Peak effect time is the time taken to reach the maximum response, onset of response is the time taken for the response to start, and threshold level is the minimum dose or concentration required to produce a response. Therefore, A is the correct answer as it is the only choice that is not a time-related measure in this context.