medical microbiology test bank

Correct Answer: A

Rationale: The correct answer is A: Clostridium botulinum. This bacterium produces the neurotoxin responsible for botulism. It thrives in anaerobic environments like improperly canned foods. Clostridium difficile (B) causes colitis, not botulism. Staphylococcus aureus (C) causes food poisoning but not botulism. Escherichia coli (D) can cause gastrointestinal illness but not botulism.

Correct Answer: A

Rationale: Saddle nose is a condition where the bridge of the nose collapses, a characteristic feature of congenital syphilis. This occurs due to inflammation and destruction of cartilage. Syphilis is caused by the bacterium Treponema pallidum. CMV, Rubella, and Toxoplasmosis do not typically cause saddle nose. CMV can result in hearing loss, Rubella can lead to cataracts and heart defects, and Toxoplasmosis may cause hydrocephalus or chorioretinitis.

Correct Answer: C

Rationale: The correct answer is C: Endospore. Endospores are highly resistant structures formed by certain bacterial species to withstand harsh conditions like desiccation. They contain a tough outer layer that protects the bacterial DNA and other essential components. Capsules (choice A) provide protection against host immune responses but not specifically against desiccation. Flagella (choice B) are used for bacterial motility. Pili (choice D) are involved in bacterial adhesion but do not protect against desiccation. Therefore, endospores are the most suitable choice for protecting against desiccation.

Correct Answer: B

Rationale: The correct answer is B because the presence of calcium dipicolinate in bacterial spores helps protect their DNA from damage under harsh conditions. Calcium dipicolinate acts as a stabilizer, preserving the spore structure. Choice A is incorrect as bacterial spores have a tough protein coat, not a lipid-rich membrane. Choice C is incorrect as bacterial spores have very low metabolic activity. Choice D is incorrect as bacterial spores have low water content to prevent damage during harsh conditions.

Correct Answer: A

Rationale: The correct answer is A: The lysozyme hydrolyzes the glycoside bonds between the N-acetylmuramic acid and the N-acetylglucosamine in the peptidoglycan of the cell wall. This is because lysozyme is an enzyme that specifically targets the peptidoglycan layer of bacterial cell walls, breaking down the structure by cleaving the glycosidic bonds between these two specific sugar molecules. This action weakens the cell wall, leading to bacterial cell lysis. The other choices are incorrect because lysozyme does not target phosphate bonds in phospholipids (B), disulfide bonds in immunoglobulins (C), or hydrogen bonds in bacterial capsules (D).