microbiology chapter 12 test bank

Correct Answer: B

Rationale: The correct answer is B: bioavailability. Bioavailability refers to the extent and rate at which a drug reaches its site of action in the body. This includes factors such as absorption, distribution, metabolism, and excretion. Rationale: 1. Bioactivity refers to the pharmacological effect of a drug, not how effectively it reaches its site of action. 2. Bioremediation is the process of using organisms to remove or neutralize pollutants, not related to drug delivery. 3. Biostasis refers to a state of equilibrium or balance in living organisms, not related to drug transport to its site of action. In summary, bioavailability is the most appropriate term as it specifically addresses the process of a drug reaching its intended target within the body, distinguishing it from the other choices.

Correct Answer: A

Rationale: The correct answer is A: Clostridium botulinum. This bacterium produces the botulinum neurotoxin, which causes paralysis by blocking the release of acetylcholine at neuromuscular junctions. Clostridium perfringens causes gas gangrene, not paralysis. Escherichia coli is associated with gastrointestinal infections, not paralysis. Staphylococcus aureus produces enterotoxins causing food poisoning, not paralysis. Therefore, Clostridium botulinum is the correct choice based on its well-known association with paralysis due to botulinum neurotoxin production.

Correct Answer: D

Rationale: The correct answer is D because all three bacteria listed are capable of producing exotoxins that can cause severe diarrhea. Escherichia coli can produce toxins that lead to diarrhea. Clostridium botulinum produces a neurotoxin causing botulism, which can also result in diarrhea. Vibrio cholerae is known for producing cholera toxin, a potent exotoxin that causes severe watery diarrhea. The other choices are incorrect because each bacterium listed is capable of producing a toxin that can cause diarrhea.

Correct Answer: D

Rationale: The correct answer is D because all measures mentioned are important in preventing hospital-acquired infections. Isolating the source helps prevent the spread of infections. Isolating at-risk patients reduces their exposure. Increasing patient resistance to infections through proper hygiene and immunizations minimizes susceptibility. Each measure plays a crucial role in infection prevention, making all options correct.

Correct Answer: D

Rationale: The correct answer is D, "All of the above," because all three bacteria listed (Vibrio cholerae, Clostridium difficile, Escherichia coli) produce toxins that can cause severe gastrointestinal illness. Vibrio cholerae produces cholera toxin leading to severe diarrhea. Clostridium difficile produces toxins causing antibiotic-associated diarrhea. Escherichia coli can produce toxins such as Shiga toxin causing severe gastrointestinal symptoms. Therefore, all the options listed are correct in producing toxins that can result in severe gastrointestinal illness.