Endocrinology Practice Questions

Correct Answer: C

Rationale: Elevated glucose levels in obese individuals are often due to insulin resistance. Insulin resistance occurs when the body's cells do not respond effectively to insulin, leading to decreased glucose uptake. This results in elevated blood glucose levels. Diabetic acidosis (choice A) is a complication of uncontrolled diabetes characterized by high blood ketone levels, not directly related to obesity. Glucose intolerance (choice B) refers to the body's inability to regulate blood glucose levels efficiently but is not specific to obesity. Insulin deficiency (choice D) is characteristic of type 1 diabetes, where the body does not produce enough insulin, which is distinct from insulin resistance seen in obesity.

Correct Answer: B

Rationale: The correct answer is B: Cretinism. Cretinism is the most common cause of preventable mental deficiency worldwide due to severe iodine deficiency during pregnancy. Iodine is crucial for thyroid hormone production, which is essential for fetal brain development. Beriberi disease (A) is caused by thiamine deficiency and affects the nervous system, not mental deficiency. Folate deficiency (C) can cause neural tube defects but not mental deficiency. Vitamin A deficiency (D) can lead to blindness and immune system issues, but not the most common cause of preventable mental deficiency.

Correct Answer: A

Rationale: The correct answer is A because Klinefelter's syndrome is characterized by small, soft testes due to the presence of an extra X chromosome (47, XXY). This leads to hypogonadism and inadequate testosterone production, resulting in underdeveloped testes. Choice B (46, XO) is incorrect as it refers to Turner syndrome. Choice C (upper segment> lower segment) is unrelated to Klinefelter's syndrome. Choice D (Gynaecomastia) is a symptom of Klinefelter's syndrome but not the defining characteristic.

Correct Answer: C

Rationale: Sertoli cells are responsible for producing and secreting Androgen binding globulin (ABG). They play a crucial role in supporting spermatogenesis by providing structural and nutritional support to developing sperm cells. ABG helps in the transport of testosterone and other androgens within the seminiferous tubules, aiding in the regulation of spermatogenesis. Testosterone is primarily produced by Leydig cells in the testes, not by Sertoli cells, making option A incorrect. Option B, Oestrogen, is mainly synthesized in the ovaries, while Sertoli cells do not produce GnRH (option D), which is secreted by the hypothalamus. Therefore, the correct answer is C, as Sertoli cells are primarily responsible for producing and secreting Androgen binding globulin.

Correct Answer: C

Rationale: The correct answer is C: Oxytocin. The anterior pituitary gland produces several hormones, including adrenocorticotropic hormone (A), growth hormone (B), and thyroid-stimulating hormone (D). Oxytocin is actually produced by the posterior pituitary gland, not the anterior pituitary. Oxytocin is responsible for uterine contractions during childbirth and milk ejection during breastfeeding. Therefore, C is the correct answer as it is not produced by the anterior pituitary unlike the other hormones mentioned.