microbiology basic and clinical principles test bank

Correct Answer: A

Rationale: The correct answer is A: Pseudomonas aeruginosa. P. aeruginosa is a Gram-negative rod that is oxidase-positive and lactose non-fermenting. The positive oxidase test indicates the presence of cytochrome c oxidase, a characteristic of P. aerugin. E. coli is lactose fermenting. Salmonella and Shigella are also Gram-negative rods, but they are lactose fermenters, unlike the lactose non-fermenting P. aeruginosa.

Correct Answer: A

Rationale: The correct answer is A: Head lice. Epidemic typhus is transmitted by the body louse, Pediculus humanus humanus, which is different from the head louse, Pediculus humanus capitis. Head lice are not known to transmit epidemic typhus. Body lice are the primary vectors for transmitting epidemic typhus. Fleas are vectors for other diseases such as plague, not epidemic typhus. Ticks are vectors for various diseases but not for epidemic typhus. Therefore, the correct vector for epidemic typhus transmission is body lice, making choice A the correct answer.

Correct Answer: A

Rationale: The correct answer is A: destruction of the local blood supply. In osteomyelitis, the infection occurs in the bone, which has a relatively poor blood supply compared to soft tissues. This limited blood flow makes it challenging for antibiotics to reach the infection site effectively, hindering their ability to combat the infection. Destruction of the local blood supply restricts the delivery of antibiotics and immune cells to the infected bone, leading to poor treatment outcomes. Summary: - Option A is correct because the limited blood supply in bones hinders antibiotic delivery. - Option B is incorrect as denaturing by normal flora does not impact antibiotic reach to the infection site. - Option C is incorrect as inflammation and edema, while present, do not primarily hinder antibiotic delivery. - Option D is incorrect as excessive pus production does not directly impede antibiotic access to the infection site.

Correct Answer: A

Rationale: The correct answer is A because Gram-negative bacteria have a unique cell envelope structure consisting of a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane. The cytoplasmic membrane is the innermost layer that separates the cytoplasm from the external environment. The peptidoglycan layer provides structural support to the cell. The outer membrane acts as an additional protective barrier and contains lipopolysaccharides. Choice B is incorrect because Gram-negative bacteria have an outer membrane in addition to the cytoplasmic membrane and peptidoglycan layer. Choice C is incorrect because Gram-negative bacteria have more than just a peptidoglycan layer in their cell envelope. Choice D is incorrect as the cell envelope of Gram-negative bacteria does have specific components.

Correct Answer: A

Rationale: The correct answer is A: ED50. The time response does not measure the ED50 because ED50 refers to the effective dose needed to produce a response in 50% of the population, which is a dose-related concept, not a time-related one. Peak effect time, onset of response, and threshold level are all time-related measures in pharmacology. Peak effect time is the time taken to reach the maximum response, onset of response is the time taken for the response to start, and threshold level is the minimum dose or concentration required to produce a response. Therefore, A is the correct answer as it is the only choice that is not a time-related measure in this context.