Microbiology An Introduction 12th Edition Test Bank

Correct Answer: A

Rationale: The correct answer is A: T-lymphocytes. In skin mycosis, a disorder of cellular immunity indicates a deficiency in T-lymphocytes, which play a crucial role in cell-mediated immunity. T-lymphocytes are responsible for recognizing and destroying infected cells. Reduction in T-lymphocytes impairs the body's ability to fight fungal infections. Incorrect choices: B: Immunoglobulin G - Immunoglobulin G is involved in humoral immunity, not cellular immunity. C: Immunoglobulin E - Immunoglobulin E is typically associated with allergic responses, not cellular immunity. D: B-lymphocytes - B-lymphocytes are responsible for producing antibodies in humoral immunity, not directly involved in cell-mediated immunity.

Correct Answer: A

Rationale: The correct answer is A: Transformation. During transformation, bacteria take up foreign DNA from the environment and incorporate it into their own genetic material. This process allows for genetic diversity and adaptation. Transduction (B) involves transfer of DNA via a virus, conjugation (C) involves direct transfer of DNA between bacterial cells, and binary fission (D) is a form of asexual reproduction in bacteria. Transformation is the only process specifically related to bacteria taking up foreign DNA.

Correct Answer: D

Rationale: The correct answer is D: Clostridium botulinum. This bacterium produces botulinum toxin, which blocks neuromuscular transmission by inhibiting the release of acetylcholine at the neuromuscular junction. This leads to muscle weakness and paralysis. Shigella dysenteriae (A) causes dysentery but does not affect neuromuscular transmission. Clostridium tetani (B) produces tetanus toxin, which affects inhibitory neurons in the spinal cord, leading to muscle spasm. Corynebacterium diphtheriae (C) produces diphtheria toxin, which affects protein synthesis in cells, not neuromuscular transmission.

Correct Answer: A

Rationale: The correct answer is A: viral DNA polymerase. Herpesviruses require viral DNA polymerase for viral DNA replication. This enzyme is responsible for synthesizing new DNA strands using existing viral DNA as a template. Ribonucleotide reductase (B) is not directly involved in DNA replication but in the synthesis of deoxyribonucleotides. Neuraminidase (C) is an enzyme found in influenza viruses, not herpesviruses. Thymidine kinase (D) is involved in nucleotide metabolism but is not essential for viral DNA replication in herpesviruses.

Correct Answer: B

Rationale: The correct answer is B: intravenous administration. This route bypasses the first-pass metabolism, allowing the drug to directly enter the bloodstream for immediate distribution. In contrast, on the skin (A) and sublingual (D) routes have slower absorption rates due to barriers like skin layers or mucous membranes. Intramuscular (C) absorption is slower than intravenous due to slower perfusion rates in muscle tissues. Overall, intravenous administration provides the fastest and most direct route for drug absorption, making it the most rapid method.