Microbiology Chapter 10 Test Bank

Correct Answer: A

Rationale: The correct answer is A: Neutralization reaction. This is the most appropriate serological test to reveal botulinum toxin because it involves mixing the patient's serum with known botulinum antitoxin. If the patient's serum contains botulinum toxin, it will neutralize the antitoxin, leading to a lack of toxin-neutralizing ability. The other choices are incorrect because agglutination reaction involves clumping of cells, not suitable for detecting botulinum toxin; Bordet-Gengou test is used to detect antibodies in pertussis infection, not botulinum toxin; and precipitation reaction involves the formation of a solid when two solutions are mixed, not ideal for detecting botulinum toxin.

Correct Answer: A

Rationale: The correct answer is A: Doxycycline. It is a broad-spectrum antibiotic effective against a wide range of bacteria, including those causing infections like Lyme disease and pneumonia. Doxycycline is often the first-line treatment for these infections due to its efficacy and low risk of resistance. Chloramphenicol (B) has serious side effects and is reserved for specific cases. Penicillin (C) is not effective against all bacteria and may not cover the specific infection. Streptomycin (D) is mainly used for certain types of bacterial infections and is not the optimal choice for the conditions mentioned in the question.

Correct Answer: A

Rationale: The correct answer is A: Yersinia pestis. Y. pestis is a Gram-negative rod that exhibits a 'safety pin' appearance on staining due to bipolar staining. This bacterium is the causative agent of plague, which can present as painful ulcers known as buboes. Y. pestis is transmitted by fleas and can cause outbreaks in humans. Summary: - B: Francisella tularensis causes tularemia, not typically associated with painful ulcers. - C: Brucella abortus causes brucellosis, which does not typically present with painful ulcers. - D: Clostridium botulinum causes botulism, characterized by muscle weakness and paralysis, not painful ulcers.

Correct Answer: B

Rationale: The correct answer is B: Gamma globulin, as it is not a primary immunodeficiency disease. Primary immunodeficiency diseases are genetic disorders that affect the immune system's ability to fight infections. A: Glanzmann-Riniker hypergammaglobulinemia is a rare primary immunodeficiency characterized by elevated levels of gammaglobulins. C: Variable hypogammaglobulinemia is a primary immunodeficiency disease where there are fluctuating levels of gammaglobulins. D: Bruton hypogammaglobulinemia, also known as X-linked agammaglobulinemia, is a primary immunodeficiency characterized by a lack of B cells and gammaglobulins. In summary, B is the correct answer as gamma globulin is not a primary immunodeficiency disease, whereas A, C, and D are all examples of primary immunodeficiency diseases affecting gammaglobulins levels.

Correct Answer: D

Rationale: The correct answer is D because utilizing all three methods�immunofluorescence, viral neutralization reaction, and electron microscopy�provides a comprehensive and rapid diagnosis of various viral infections. Immunofluorescence detects viral antigens directly, viral neutralization reaction demonstrates the presence of specific antibodies, and electron microscopy visualizes viral particles. This combination ensures accurate and quick identification of different viruses. Choices A, B, and C alone may not cover all aspects of viral diagnosis, making them less effective compared to the comprehensive approach of using all three methods.