Microbiology An Introduction 12th Edition Test Bank

Correct Answer: A

Rationale: The correct answer is A: Streptomycin. Streptomycin is an aminoglycoside antibiotic used to treat tuberculosis that can cause hearing loss as a side effect. It is known to damage the cochlear and vestibular organs in the inner ear. The other choices, B: Isoniazid, C: Rifampicin, and D: Ethionamide, are not associated with causing hearing deterioration as a side effect. Isoniazid can rarely cause peripheral neuropathy, Rifampicin can lead to hepatotoxicity, and Ethionamide may cause gastrointestinal disturbances, but none of these drugs are known to specifically cause hearing loss.

Correct Answer: D

Rationale: The correct answer is D: Hyaluronidase synthesis. Hyaluronidase is an enzyme produced by some pathogens to break down hyaluronic acid in the extracellular matrix, aiding their spread. This action does not directly counteract the immune system's mechanisms. Antigenic heterogeneity and mimicry can evade immune recognition. IgA proteases degrade IgA antibodies, impairing mucosal immunity. Therefore, D is the only choice not directly involved in counteracting the immune system.

Correct Answer: A

Rationale: The correct answer is A: viral DNA polymerase. Herpesviruses require viral DNA polymerase for viral DNA replication. This enzyme is responsible for synthesizing new DNA strands using existing viral DNA as a template. Ribonucleotide reductase (B) is not directly involved in DNA replication but in the synthesis of deoxyribonucleotides. Neuraminidase (C) is an enzyme found in influenza viruses, not herpesviruses. Thymidine kinase (D) is involved in nucleotide metabolism but is not essential for viral DNA replication in herpesviruses.

Correct Answer: A

Rationale: The correct answer is A: Tetanus. Tetanus is caused by the bacterium Clostridium tetani, which produces a toxin affecting the nervous system. Symptoms such as malaise, irritability, muscular twitching, and high body temperature are characteristic of tetanus due to muscle spasms and rigidity. The 15-day incubation period after trauma aligns with the typical onset of tetanus symptoms. Incorrect choices: B: Anaerobic gas gangrene - This condition usually presents with localized tissue necrosis and gas bubbles in the affected area, not systemic symptoms like malaise and headache. C: Erysipelas - This is a bacterial skin infection presenting with red, swollen patches, not the neurological symptoms seen in tetanus. D: Acute thrombophlebitis - This is a blood clot in a vein causing pain and swelling, not associated with the systemic symptoms and muscle twitching seen in tetanus.

Correct Answer: A

Rationale: The correct answer is A: Genus Shigella. Shigella is known to be the causative agent of bacterial dysentery. It invades the intestinal lining, leading to symptoms like severe diarrhea and abdominal cramps. Salmonella (choice B) typically causes food poisoning, not dysentery. Klebsiella (choice C) is associated with pneumonia and urinary tract infections, not dysentery. "None of the above" (choice D) is incorrect as Shigella does belong to a specific genus responsible for bacterial dysentery.