Foundations and Adult Health Nursing Study Guide Answers

Correct Answer: A

Rationale: Somatic hypermutation is the mechanism responsible for generating diversity in the antigen-binding sites of immunoglobulins. During somatic hypermutation, point mutations are introduced into the variable regions of immunoglobulin genes in B cells. These mutations occur randomly and lead to a wide range of amino acid changes in the antigen-binding sites of antibodies. As a result, a diverse repertoire of antibodies with varying specificities for different antigens is created. Gene rearrangement and isotype switching are other mechanisms that contribute to antibody diversity but do not specifically target the antigen-binding sites. Clonal expansion, on the other hand, refers to the proliferation of specific B cell clones after activation by antigens, which amplifies the immune response but does not directly impact the diversity of antigen-binding sites.

Correct Answer: B

Rationale: One of the major differences between Hodgkin's lymphoma and non-Hodgkin's lymphoma is that Hodgkin's lymphoma is considered potentially curable, while non-Hodgkin's lymphoma is typically not curable. Hodgkin's lymphoma is characterized by the presence of Reed-Sternberg cells, which are not found in non-Hodgkin's lymphoma. Additionally, Hodgkin's lymphoma tends to spread in a more orderly and predictable manner through the lymph nodes, making it easier to treat and potentially cure with the appropriate combination of chemotherapy, radiation therapy, and stem cell transplant. On the other hand, non-Hodgkin's lymphoma is a diverse group of lymphomas that can vary greatly in presentation, behavior, and response to treatment, with some subtypes being more aggressive and resistant to treatment. Therefore, the potential for cure is higher in Hodgkin's lymphoma compared to non-Hodgkin's lymph

Correct Answer: C

Rationale: Mast cells are primarily responsible for mediating allergic responses such as severe allergies. When an allergen triggers the immune response, mast cells release histamine, leukotrienes, and other inflammatory mediators. These substances cause symptoms such as difficulty breathing, hives, and swelling. Basophils also release histamine, but mast cells are more abundant in tissues and play a significant role in allergic reactions. Eosinophils are involved in allergic reactions but are more focused on combating parasitic infections. Neutrophils are not typically involved in allergic responses but play a key role in combating bacterial infections.

Correct Answer: C

Rationale: Type 2 diabetes mellitus is characterized by insulin resistance in the peripheral tissues and defective beta cell secretion with loss of insulin. In type 2 diabetes, there is typically not destruction of beta cells from an autoimmune mechanism that leads to lack of insulin and hyperglycemia as seen in type 1 diabetes mellitus. Instead, in type 2 diabetes, the pancreas initially produces insulin, but the body's cells become resistant to its effects. This results in hyperglycemia due to the inability of the body to properly regulate blood sugar levels. Therefore, choice C is not true for type 2 diabetes mellitus.

Correct Answer: D

Rationale: A correlational research design is most appropriate when the aim is to find a relationship between two variables. Correlational studies examine how variables are related to each other without manipulating them. This design allows researchers to determine the strength and direction of the relationship between variables, providing valuable insights into the potential associations between different factors. Phenomenological studies focus on understanding individuals' experiences, exploratory studies investigate a topic without predefined hypotheses, and experimental studies involve manipulating variables to observe their effects. Therefore, in the context of aiming to find a relationship between two variables, a correlational research design is the most suitable choice.