Proctored Pharmacology ATI

Correct Answer: C

Rationale: Propranolol undergoes extensive first-pass metabolism in the liver. When administered orally, propranolol is extensively metabolized by the liver before reaching systemic circulation, leading to reduced bioavailability. This process is known as first-pass hepatic metabolism, which significantly affects the drug's effectiveness and necessitates higher oral doses compared to other routes of administration.

Correct Answer: B

Rationale: Grapefruit juice can inhibit the metabolism of amlodipine, a calcium channel blocker, leading to increased drug levels in the blood. This can result in potentiated side effects and potential toxicity. Therefore, it is important for the client to avoid grapefruit juice while taking amlodipine.

Correct Answer: A

Rationale: An INR of 4.0 indicates that the client's blood is clotting too slowly, increasing the risk of bleeding. This level is above the therapeutic range for a client on Warfarin therapy. Therefore, the healthcare professional should notify the provider immediately to prevent potential bleeding complications.

Correct Answer: A

Rationale: Acetaminophen is known to lose its effectiveness in controlling pain beyond a dosage of 1,000 mg. It is important to adhere to recommended dosages to ensure optimal pain relief and avoid potential adverse effects associated with higher doses.

Correct Answer: C

Rationale: The correct answer is 'C: Eye damage.' Eye damage, such as retinopathy, is a severe adverse effect of Hydroxychloroquine, and clients should be informed to report any changes in vision immediately to prevent permanent visual impairment.