ATI RN
mastering microbiology test bank Questions
Question 1 of 5
By precipitation of tuberculin, a purified protein derivative (PPD) is obtained. It is used in:
Correct Answer: A
Rationale: The correct answer is A: Mantoux test. The Mantoux test is used to screen for tuberculosis by injecting PPD intradermally. The presence of a delayed hypersensitivity reaction indicates prior exposure to Mycobacterium tuberculosis. The Schick test (B) is used to test for immunity to diphtheria, while the Dick test (C) is used to test for immunity to scarlet fever. Therefore, the correct use of PPD is in the Mantoux test for tuberculosis screening.
Question 2 of 5
Tuberculosis can be treated by means of combined chemotherapy that includes substances with different mechanisms of action. What antituberculous medication inhibits transcription of RNA into DNA in mycobacteria?
Correct Answer: A
Rationale: Rifampicin is the correct answer because it inhibits RNA transcription in mycobacteria by binding to the bacterial RNA polymerase. This prevents the synthesis of RNA, leading to the inhibition of protein production essential for bacterial growth. Isoniazid inhibits mycolic acid synthesis, Streptomycin inhibits protein synthesis, and Ethionamide disrupts mycolic acid synthesis. These mechanisms are different from inhibiting RNA transcription, making them incorrect choices.
Question 3 of 5
Which of the following pathogens has the widest infectious spectrum
Correct Answer: A
Rationale: The correct answer is A, Anthrax bacillus, because it has the widest infectious spectrum among the options provided. Anthrax bacillus can infect a wide range of hosts, including humans and various animals. It is known for its ability to survive in different environments and cause disease through various routes of exposure. In contrast, choices B, C, and D have more limited infectious spectra. Mumps virus primarily infects humans, the causative agent of gonorrhea mainly affects humans through sexual contact, and the rabies virus typically infects mammals through bites from infected animals. Therefore, Anthrax bacillus is the correct choice due to its broader range of hosts and modes of transmission compared to the other options.
Question 4 of 5
The First-line tuberculosis drugs include:
Correct Answer: A
Rationale: The correct answer is A: Isoniazid and rifampicin. These drugs are considered first-line treatment for tuberculosis due to their high efficacy and low toxicity. Isoniazid targets the cell wall of the tuberculosis bacteria, while rifampicin inhibits RNA synthesis. They are recommended by WHO as the first choice for treating tuberculosis. Choice B (Penicillin and erythromycin) is incorrect because these antibiotics are not effective against tuberculosis bacteria. Choice C (Trimethoprim and third generation cephalosporins) is incorrect because they are not considered first-line drugs for tuberculosis treatment. Choice D (All the listed above can be used depending on their resistance profile) is incorrect because only isoniazid and rifampicin are universally recognized as first-line drugs for tuberculosis regardless of resistance profile.
Question 5 of 5
While examining the feces of a patient with diarrhea, cysts with four nuclei were found. What protozoan is most likely causing the condition?
Correct Answer: A
Rationale: The correct answer is A: Entamoeba histolytica. This protozoan causes amoebiasis, which presents with symptoms like diarrhea. The cysts with four nuclei found in the feces are characteristic of Entamoeba histolytica. This protozoan is known to cause invasive infection, leading to tissue destruction and ulcers in the intestines. Lamblia (choice B) typically presents with cysts containing two nuclei. Trichomonas (choice C) is a sexually transmitted parasite and does not form cysts. Balantidium (choice D) is a ciliated protozoan that does not have four nuclei in its cyst form.
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