ATI RN
Mastering Microbiology Test Bank Questions
Question 1 of 5
A 40-year-old patient presents with abdominal pain, frequent loose stools with mucus and blood. Stool analysis revealed vegetative forms of some protozoa sized 30-40 microns, with short pseudopodia, containing large amounts of phagocytosed erythrocytes. What protozoan disease does the patient have?
Correct Answer: A
Rationale: The correct answer is Amebiasis. The patient's symptoms of abdominal pain, loose stools with mucus and blood, along with the presence of protozoa containing phagocytosed erythrocytes in stool analysis are indicative of Entamoeba histolytica infection. The size (30-40 microns) and pseudopodia characteristics match E. histolytica. Amebiasis commonly presents with dysentery, while Leishmaniasis (B) typically causes skin ulcers. Trichomoniasis (C) is a sexually transmitted infection, not associated with the described symptoms. Giardiasis (D) is characterized by foul-smelling diarrhea and steatorrhea, not bloody diarrhea as seen in this case.
Question 2 of 5
On the 5th day after a surgery for colon injury a patient complains of bursting pain in the postoperative wound, weakness, drowsiness, headache, fever up to 40oC. Objectively: the skin around the wound is swollen, there is gas crepitation. The wound discharges are scarce foul-smelling, of dark-gray color. What is the most likely diagnosis?
Correct Answer: A
Rationale: The correct answer is A: Anaerobic clostridial wound infection. The symptoms and signs described (bursting pain, weakness, drowsiness, fever, swollen skin, gas crepitation, foul-smelling dark-gray discharge) are classic for gas gangrene, caused by Clostridium perfringens. Gas gangrene is an anaerobic infection that thrives in devitalized tissue, such as postoperative wounds. The gas crepitation is due to gas production by the bacteria. Abscess (B) typically presents with localized swelling and fluctuance, not gas crepitation. Postoperative wound infection (C) may present with redness, warmth, and increased wound discharge but not the specific features mentioned. Erysipelas (D) is a superficial bacterial skin infection, typically caused by Streptococcus pyogenes, presenting with well-defined raised borders and redness.
Question 3 of 5
Tuberculosis can be treated by means of combined chemotherapy that includes substances with different mechanisms of action. What antituberculous medication inhibits transcription of RNA into DNA in mycobacteria?
Correct Answer: A
Rationale: Rifampicin is the correct answer because it inhibits RNA transcription in mycobacteria by binding to the bacterial RNA polymerase. This prevents the synthesis of RNA, leading to the inhibition of protein production essential for bacterial growth. Isoniazid inhibits mycolic acid synthesis, Streptomycin inhibits protein synthesis, and Ethionamide disrupts mycolic acid synthesis. These mechanisms are different from inhibiting RNA transcription, making them incorrect choices.
Question 4 of 5
Which of the following bacteria causes the disease diphtheria?
Correct Answer: B
Rationale: The correct answer is B: Corynebacterium diphtheriae. This bacterium produces a toxin that causes diphtheria by inhibiting protein synthesis, leading to the formation of a pseudomembrane in the throat. Bordetella pertussis causes whooping cough, Streptococcus pyogenes causes strep throat, and Neisseria meningitidis causes meningitis. Corynebacterium diphtheriae is the only bacterium among the choices known to cause diphtheria due to its specific toxin production.
Question 5 of 5
Pseudomonas aeruginosa can cause:
Correct Answer: A
Rationale: Step-by-step rationale for answer A: 1. Pseudomonas aeruginosa is known to cause burn wounds infections due to its ability to survive in moist environments. 2. It can cause severe pneumonia in patients with cystic fibrosis due to its resistance to antibiotics and ability to form biofilms. 3. It is a common cause of nosocomial infections in hospitals due to its ability to colonize medical equipment and surfaces. Summary of other choices: B. Pseudomonas aeruginosa typically does not cause food poisoning, as it is not a common pathogen associated with foodborne illnesses. C. Bacterial pharyngitis is usually caused by Streptococcus pyogenes, not Pseudomonas aeruginosa, making this choice incorrect. D. None of the above is incorrect as Pseudomonas aeruginosa is associated with specific infections mentioned in option A.
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