Pharmacology HESI 55 Questions 2023

Correct Answer: A

Rationale: The correct answer is A: Bone marrow suppression. Methotrexate, commonly used in rheumatoid arthritis, can lead to bone marrow suppression, reducing the production of blood cells and increasing the risk of infection. Monitoring for signs of anemia, leukopenia, and thrombocytopenia is crucial to detect bone marrow suppression early and prevent complications.

Correct Answer: D

Rationale: The effectiveness of amiodarone is best assessed by a reduction in irregular heartbeats, as it is primarily used to treat ventricular dysrhythmias. Angina spells, ankle swelling, and cholesterol levels are not direct indicators of amiodarone's effectiveness.

Correct Answer: C

Rationale: The correct answer is C. Enalapril, an ACE inhibitor, inhibits the conversion of angiotensin I to angiotensin II, leading to increased levels of bradykinin. The accumulation of bradykinin is responsible for the persistent dry cough associated with ACE inhibitors like enalapril.

Correct Answer: B

Rationale: To accurately determine peak and trough levels of vancomycin, blood should be drawn two hours after the completion of the IV dose and 30 minutes before the next dose. This timing allows for appropriate assessment of the drug levels in the body, ensuring accurate monitoring of therapeutic and toxic concentrations.

Correct Answer: A

Rationale: Dapagliflozin, a medication used in diabetes mellitus type 2, is associated with an increased risk of genital infections. This risk is due to its mechanism of action that involves promoting the excretion of glucose through the urine, creating a favorable environment for microbial growth in the genital area. Therefore, monitoring for genital infections is essential when a client is prescribed dapagliflozin.