Pediatric HESI 2023

Correct Answer: A

Rationale: Trisomy 21, also known as Down syndrome, is caused by nondisjunction, which is an error in cell division that leads to the presence of an extra chromosome 21. This additional chromosome alters the normal genetic makeup, resulting in the characteristics associated with Down syndrome. Therefore, the correct answer is nondisjunction (Choice A). Choices B, C, and D are incorrect because Trisomy 21 is not caused by X-linked recessive inheritance, genomic imprinting, or autosomal dominant inheritance. Understanding the specific genetic mechanism involved in Trisomy 21 is crucial for grasping the basis of this chromosomal disorder.

Correct Answer: A

Rationale: The correct answer is A: nondisjunction. Trisomy 21, also known as Down syndrome, is caused by nondisjunction, which is an error in cell division leading to an extra copy of chromosome 21. This additional genetic material alters the course of development and causes the characteristics associated with Down syndrome. Choices B, C, and D are incorrect. X-linked recessive inheritance refers to genetic disorders carried on the X chromosome, genomic imprinting involves gene expression based on parental origin, and autosomal dominant inheritance relates to disorders caused by a dominant gene on one of the non-sex chromosomes. In the case of trisomy 21, the cause is specifically related to the error in chromosome division, making nondisjunction the most appropriate answer.

Correct Answer: A

Rationale: Corticosteroids are the mainstay of treatment for minimal change nephrotic syndrome as they help reduce inflammation and decrease proteinuria. Antihypertensive agents are used to manage high blood pressure often associated with kidney disease but are not the primary treatment for this condition. Long-term diuretics are not typically used in the management of minimal change nephrotic syndrome as they can worsen fluid and electrolyte imbalances. Increasing fluids to promote diuresis is not recommended in this condition as it can lead to further fluid retention and edema.

Correct Answer: C

Rationale: Abnormal heart sounds could indicate a congenital heart defect, which is common in infants with Down syndrome.

Correct Answer: B

Rationale: The priority nursing intervention for a 7-year-old child with type 1 diabetes mellitus is monitoring blood glucose levels. This is crucial for managing and adjusting insulin therapy to maintain blood glucose within the target range. Administering insulin as prescribed is important but should be based on monitoring blood glucose levels. Teaching the child how to self-administer insulin may be appropriate for older children but may not be the priority for a 7-year-old. Encouraging regular exercise is a valuable aspect of diabetes management but is not the immediate priority over monitoring blood glucose levels.